We investigated magnetoresistance in wedged Fe/Cr multilayers grown at several sputtering pressures. Low angle X-ray scattering showed that interface roughness increased with higher sputtering pressure. The increased roughness was accompanied by an increase in saturation resistance, which results in a decrease in fractional magnetoresistance. The maximum magnetoresistance (measured at room temperature) was 7.3 and 4.0% for the films grown at 1.4 and 10 mT Ar, respectively, both at the region with 13 angstrom Cr layers.