LACK OF INFLUENCE OF NONINHERITED MATERNAL HLA-DR ALLELES ON SUSCEPTIBILITY TO RHEUMATOID-ARTHRITIS

被引：12

作者：

SILMAN, AJ ^{[1
]}

HAY, EM ^{[1
]}

WORTHINGTON, J ^{[1
]}

THOMSON, W ^{[1
]}

PEPPER, L ^{[1
]}

DAVIDSON, J ^{[1
]}

DYER, PA ^{[1
]}

OLLIER, WER ^{[1
]}

机构：

[1] ST MARYS HOSP,N W TISSUE TYPING LAB,MANCHESTER,LANCS,ENGLAND

来源：

ANNALS OF THE RHEUMATIC DISEASES | 1995年 / 54卷 / 04期

关键词：

D O I：

10.1136/ard.54.4.311

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objective-To reproduce findings from previous reports that non-inherited maternal HLA class II antigens might contribute to rheumatoid arthritis (RA) susceptibility in the offspring. Methods-Families were recruited from the Arthritis and Rheumatism Council's National Repository of RA families and HLA-DRB1 alleles were examined in these individuals and their first degree relatives using DNA typing methods. Results-There was no evidence of an increase in either non-inherited maternal HLA-DR4 or the HLA-DRB1 shared epitope as a whole compared with the frequency expected using the noninherited paternal antigens as controls. Conclusions-The numbers of probands who were shared epitope negative were small, but we are unable to confirm in these families the findings that non-inherited maternal HLA contributes an additional susceptibility factor to rheumatoid arthritis.

引用

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页码：311 / 313

页数：3

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