EFFECT OF TRANSFORMING GROWTH-FACTOR-ALPHA ON GASTRIC-ACID SECRETION IN RATS AND MONKEYS

被引：28
|
作者：
GUGLIETTA, A [1 ]
LESCH, CA [1 ]
ROMANO, M [1 ]
MCCLURE, RW [1 ]
COFFEY, RJ [1 ]
机构：
[1] VANDERBILT UNIV,DEPT MED & CELL BIOL,NASHVILLE,TN
来源：
DIGESTIVE DISEASES AND SCIENCES | 1994年 / 39卷 / 01期
关键词：
TGF-ALPHA; EGF; GASTRIC ACID SECRETION; MONKEYS;
D O I：
10.1007/BF02090079
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
The effect of transforming growth factor-alpha was studied in histamine-stimulated gastric acid secretion in monkeys and in pylorus-ligated rats. In monkeys, transforming growth factor-alpha given intravenously in a stepwise manner gradually reduced gastric acid secretion. A dose of 0.1 nmol/kg induced about a 50% inhibition of gastric acid output, while about 100% inhibition of the same parameter, was observed after a dose of 1 nmol/kg. Following a single administration of 1 nmol/kg intravenously in monkey, the maximum inhibitory effect on gastric acid output was reached 60 min after the administration of the drug, when a 91.8% inhibition was observed. Pretreatment values were reached 210-240 min after transforming growth factor-alpha administration. In pylorus-ligated rats, transforming growth factor-alpha, at doses of 9 and 18 nmol/kg produced art almost complete inhibition of gastric acid secretion. In this model, the ED(50) was calculated to be 4.5 nmol/kg. Comparison with epidermal growth factor on the same models of gastric acid secretion showed that these two compounds have similar inhibitory potency. However, the effect of transforming growth factor-alpha on gastric acid secretion in monkeys was shorter lasting than that of epidermal growth factor.
引用
收藏
页码：177 / 182
页数：6
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