LINKAGE ANALYSIS USING LOGLINEAR MODELS

被引：4

作者：

EDWARDS, D ^{[1
]}

机构：

[1] NOVO NORDISK PK,DK-2760 MALOV,DENMARK

来源：

COMPUTATIONAL STATISTICS & DATA ANALYSIS | 1992年 / 13卷 / 03期

关键词：

LINKAGE ANALYSIS; CHROMOSOME MAPPING; CONDITIONAL INDEPENDENCE; CONTINGENCY TABLES; GRAPHICAL MODELS; INDEPENDENCE GRAPHS; MODEL SELECTION; INTERFERENCE;

D O I：

10.1016/0167-9473(92)90136-4

中图分类号：

TP39 [计算机的应用];

学科分类号：

081203 ; 0835 ;

摘要：

Analysis of linkage between a set of genes or genetic markers is used to study their relative positions on the chromosomes. An exposition of linkage analysis is given in terms of loglinear models. It is shown that under a simplifying assumption (that of no interference) the independence graphs of the appropriate loglinear models consist of simple serial strings, exactly homologous with the chromosomes. Data from an experiment studying barley powdery mildew are analyzed by means of two loglinear model selection procedures, using asymptotic and exact tests respectively. Comparison of these and other approaches is given in a brief discussion.

引用

页码：281 / 290

页数：10

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