Overview of nanoparticle albumin-bound paclitaxel in metastatic breast cancer

被引：0
|
作者：
Strauch, Demetria Ileana [1 ]
Moreno-Aspitia, Alvaro [1 ]
机构：
[1] Mayo Clin, Div Hematol & Oncol, 4500 San Pablo Rd, Jacksonville, FL 32224 USA
来源：
BREAST CANCER MANAGEMENT | 2013年 / 2卷 / 03期
关键词：
D O I：
10.2217/BMT.13.18
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Breast cancer remains the most commonly diagnosed cancer in women in the USA and is estimated to be responsible for 14% of cancer-related deaths in 2012. Taxane chemotherapy agents are a mainstay of treatment for metastatic breast cancer, but unfortunately, significant toxicities can limit their use. Nanoparticle albumin-bound (nab)paclitaxel is a formulation of paclitaxel that is bound to an albumin nanoparticle. This allows for improved solubility as well as higher plasma clearance and volume distribution without the hypersensitivity reactions and myelosuppression of standard Cremophor (R)-based paclitaxel. This article will review nanoparticle albumin-bound paclitaxel in the treatment of metastatic breast cancer.
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收藏
页码：221 / 229
页数：9
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