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- [4] Further studies on the buffer-catalyzed cleavage and isomerization of uridyluridine. Medium and ionic strength effects on catalysis by morpholine, imidazole, and acetate buffers help clarify the mechanisms involved and their relationship to the mechanism used by the enzyme ribonuclease and by a ribonuclease mimic JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1996, 118 (28) : 6588 - 6600