ANTIBODY-PRODUCTION IN INFANTS BORN TO HIV-1-INFECTED MOTHERS

被引：0

作者：

GUERRA, E

VONHUNOLSTEIN, C

QUINTI, I

RECCHIA, S

STEGAGNO, M

VISCONTI, E

OREFICI, G

机构：

[1] UNIV ROME LA SAPIENZA,DEPT CHILD HLTH,I-00185 ROME,ITALY

[2] IST SUPER SANITA,BACTERIOL & MED MYCOL LAB,I-00161 ROME,ITALY

来源：

ZENTRALBLATT FUR BAKTERIOLOGIE-INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY VIROLOGY PARASITOLOGY AND INFECTIOUS DISEASES | 1992年 / 276卷 / 03期

关键词：

D O I：

暂无

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Naturally occurring antibodies to polysaccharide antigens of pathogens commonly isolated from HIV-1-infected subjects were analyzed in serially collected sera of children born to seropositive mothers. Purified polysaccharides from type 14 Streptococcus pneumoniae, group C Neisseria meningitidis, type b Haemophilus influenzae, glucomannoprotein from Candida albicans and diphtheria toxoid antigens were used in an ELISA test to assess antibody levels. A significant rise of anti-pneumococcus antibody titres was noticed both in HIV-1-infected and in non-HIV-1-infected children aged 18 months or more. Anti-C. albicans and anti-group C N. meningitidis antibodies were elevated only in HIV-1-infected children older than 12 months. Anti-type b H. influenzae antibodies remained at low titres in both groups. Anti-diphtheria toxoid antibodies, analyzed as a model of humoral response to a protein antigen, were similar in both groups of HIV-1-infected and noninfected children.

引用

页码：429 / 436

页数：8

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