Anti-Mullerian hormone (AMH)

Anti-Mullerian hormone (AMH) is produced by Sertoli cells in men and granulosa cells in women. It is interesting from a clinical point of view in evaluating the ovarian reserve in women of reproductive age. AMH is mainly produced by primary, secondary and early antral follicles and is therefore a marker of the growing follicle pool in the ovary. AMH correlates with age, with the number of oocytes retrieved in an in vitro fertilization (IVF) cycle and with the pregnancy and birth rate. AMH is stable over the cycle, with only a small drop after ovulation. AMH is stable and can be measured to evaluate the ovarian reserve during treatment with oral contraceptive pills and during pregnancy. AMH is also a useful tumor marker for granulosa cell tumors. In newborns or children with intersex disorders, AMH can be measured to evaluate whether or not testicular tissue is present.