SCREENING-TEST OF CRUDE DRUG EXTRACT ON ANTI-HIV ACTIVITY

被引：29
|
作者：
YAMASAKI, K [1 ]
OTAKE, T [1 ]
MORI, H [1 ]
MORIMOTO, M [1 ]
UEBA, N [1 ]
KUROKAWA, Y [1 ]
SHIOTA, K [1 ]
YUGE, T [1 ]
机构：
[1] OSAKA UNIV PHARMACEUT SCI, MATSUBARA, OSAKA 580, JAPAN
来源：
YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN | 1993年 / 113卷 / 11期
关键词：
HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 (HIV-1); ANTIVIRAL ACTIVITY; AIDS; CRUDE DRUG EXTRACT; LITHOSPERMUM ERYTHRORHIZON; PRUNELLA VULGARIS;
D O I：
10.1248/yakushi1947.113.11_818
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The anti-HIV-1 effects of 204 crude drugs of common use in Japan were evaluated in vitro. As a result, 45 samples inhibited HIV-1-induced cytopathogenicity in MT-4 cells. In particular, the hot water extracts of Lithospermum erythrorhizon (root) and Prunella vulgaris (spike) showed the strongest anti-HIV-1 activities. Their IC100 values were both 16 mu g/ml. In general, the hot water extracts of the crude drug suppressed the replication of HIV-1 growth more strongly than the cold water extracts.
引用
收藏
页码：818 / 824
页数：7
相关论文
共 50 条
  • [1] In vitro anti-HIV activity of a Chinese fungus extract
    Xiang, Zi-Chun
    Jiang, Yan
    Guo, Shun-Xing
    BIOMEDICAL AND ENVIRONMENTAL SCIENCES, 2006, 19 (03) : 169 - 172
  • [2] In Vitro Anti-HIV Activity of a Chinese Fungus Extract
    ZI-CHUN XIANG
    National Center for AIDS/STD Control and Prevention (NCAIDS)
    BiomedicalandEnvironmentalSciences, 2006, (03) : 169 - 172
  • [3] A SEMIAUTOMATED MULTIPARAMETER APPROACH FOR ANTI-HIV DRUG SCREENING
    GULAKOWSKI, RJ
    MCMAHON, JB
    STALEY, PG
    MORAN, RA
    BOYD, MR
    JOURNAL OF VIROLOGICAL METHODS, 1991, 33 (1-2) : 87 - 100
  • [4] SCREENING FOR ANTI-HIV
    KAY, LA
    LANCET, 1987, 1 (8533): : 632 - 632
  • [5] Drug-antibody conjugates with anti-HIV activity
    Paulik, M
    Grieco, P
    Kim, C
    Maxeiner, HG
    Grunert, HP
    Zeichhardt, H
    Morre, DM
    Morré, DJ
    BIOCHEMICAL PHARMACOLOGY, 1999, 58 (11) : 1781 - 1790
  • [6] Current Status of Targets and Assays for Anti-HIV Drug Screening
    Ren-rong TIAN
    Virologica Sinica, 2007, (06) : 476 - 485
  • [7] In vitro anti-HIV activity of crude extracts from Tinospora cordifolia
    Mamidala Estari
    Lunavath Venkanna
    Annem Srinivas Reddy
    BMC Infectious Diseases, 12 (Suppl 1)
  • [8] ANTI-HIV DRUG MECHANISM
    JONES, IM
    JACOB, GS
    NATURE, 1991, 352 (6332) : 198 - 198
  • [9] The Anti-HIV Drug Pipeline
    Bartlett, John G.
    JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES, 2014, 65 : 48 - 48
  • [10] Screening of some savannah plants for antiretroviral (ANTI-HIV) activity
    Mukhtar, M. D.
    Audu, A. A.
    Adoum, O. A.
    Mudi, S. Y.
    Aliyu, B. S.
    Mustapha, Y.
    Dabo, N. T.
    Bashir, M.
    Salisu, A. I.
    RETROVIROLOGY, 2009, 6
12345