BONE-RESORBING ACTIVITY OF SURFACE-ASSOCIATED MATERIAL FROM ACTINOBACILLUS-ACTINOMYCETEMCOMITANS AND EIKENELLA-CORRODENS

被引：28

作者：

MEGHJI, S

WILSON, M

BARBER, P

HENDERSON, B

机构：

[1] UNIV LONDON, EASTMAN DENT INST, DEPT MICROBIOL, LONDON WC1X 8LD, ENGLAND

[2] UNIV LONDON, EASTMAN DENT INST, ELECTRON MICROSCOPY UNIT, LONDON WC1X 8LD, ENGLAND

来源：

JOURNAL OF MEDICAL MICROBIOLOGY | 1994年 / 41卷 / 03期

基金：

英国惠康基金;

关键词：

D O I：

10.1099/00222615-41-3-197

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The results of this study demonstrate that saline extracted surface-associated material (SAM) of Actinobacillus actinomycetemcomitans and Eikenella corrodens stimulates bone resorption at picomolar concentrations. Various inhibitors of known osteolytic mediators-indomethacin, interleukin-1 receptor antagonist (IL-1ra) and a neutralising antibody to murine tumour necrosis factor (TNF)alpha-were tested to determine the mechanism of action of these SAMs. Bone resorption induced by SAM from E. corrodens was slightly inhibited by indomethacin and almost completely inhibited by blocking the action of TNF alpha; that from A. actinomycetemcomitans was not significantly affected by either of these inhibitors.

引用

页码：197 / 203

页数：7

共 15 条

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