MAMMARY EXCRETION OF CANNABIDIOL IN RABBITS AFTER INTRAVENOUS ADMINISTRATION

被引：2
|
作者：
YOO, SD
FINCHER, TK
HOLLADAY, JW
机构：
[1] Department of Basic Pharmaceutical Sciences, College of Pharmacy, University of South Carolina, Columbia, South Carolina
来源：
JOURNAL OF PHARMACY AND PHARMACOLOGY | 1994年 / 46卷 / 11期
关键词：
D O I：
10.1111/j.2042-7158.1994.tb05717.x
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The present study examined the distribution of cannabidiol into milk after an intravenous bolus injection (3 mg kg(-1)) to lactating rabbits. Drug concentrations in milk and serum were measured by HPLC. Cannabidiol was excreted into milk rapidly and the drug levels in milk increased over a 4-24-h period following the maternal injection. The mean milk to serum concentration ratio was 25.9, indicating a significant accumulation of the drug in milk.
引用
收藏
页码：926 / 928
页数：3
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