CONFORMATIONALLY RESTRICTED THIAZOLE DERIVATIVES AS NOVEL CLASS OF 5-HT3 RECEPTOR LIGANDS

被引：0

作者：

PERRONE, R ^{[1
]}

BERARDI, F ^{[1
]}

COLABUFO, NA ^{[1
]}

TORTORELLA, V ^{[1
]}

LOGRANO, MD ^{[1
]}

DANIELE, E ^{[1
]}

GOVONI, S ^{[1
]}

机构：

[1] DIPARTIMENTO FARMACOBIOL,I-70126 BARI,ITALY

来源：

FARMACO | 1995年 / 50卷 / 02期

关键词：

D O I：

暂无

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

A new series of tricyclic derivatives of 2-methyl-naphtho[1,2-d] thiazole were synthesized in order to investigate the effects of the conformational restriction of bicyclic thiazole derivatives previously reported on the 5-HT3 receptor affinity. The basic moiety in these compounds is represented by the terminal nitrogen of N-methyl-piperazine or N-methyl-piperidine ring linked at 2-methyl. All the tricyclic derivatives have a significant 5-HT3 receptor binding affinity and the terminal piperazine ring is more suitable than piperidine one.

引用

页码：77 / 82

页数：6

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