The Interaction of Clopidogrel and Proton Pump Inhibitors

被引：1
|
作者：
Arslan, Zekeriya [1 ]
Arslan, Gokhan [2 ]
Guler, Adem [2 ]
机构：
[1] GATA, Kardiyol AD, Ankara, Turkey
[2] GATA, Kalp Damar Cerrahisi AD, Ankara, Turkey
来源：
JOURNAL OF CLINICAL AND ANALYTICAL MEDICINE | 2013年 / 4卷 / 02期
关键词：
Clopidogrel; Antiplatelet; Proton Pump Inhibitors;
D O I：
10.4328/JCAM.771
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The antiplatelet agents are prescribed in acute coronary syndromes, peripheric arterial diseases, MI, and noncardioembolic stroke to decrease the atherosclerotic events and often used with proton pump inhibitors. Current studies have demonstrated considerable interaction between clopidogrel and proton pump inhibitors. PPI can lessen the effect of clopidogrel owing to the elimination of the both drugs with the cytochrom P450 isoenzymes in Liver.
引用
收藏
页码：158 / 160
页数：3
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