AN IN-VITRO STUDY OF BORONATED PORPHYRINS FOR POTENTIAL USE IN BORON NEUTRON-CAPTURE THERAPY

被引：19
|
作者：
WOODBURN, K
PHADKE, AS
MORGAN, AR
机构：
[1] Department of Chemistry, University of Toledo, Toledo
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1993年 / 3卷 / 10期
关键词：
D O I：
10.1016/S0960-894X(01)81006-4
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A series of boronated hematoporphyrin analogs differing in Lipophilicity and in the length of the di-ether side chains, and their zinc derivatives were evaluated for use in boron neutron capture therapy. The porphyrins displayed no inherent cytotoxicity towards V79 cells at a concentration of 300 mu M. Cellular uptake varied as a function of lipophilicity and metallation.
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页码：2017 / 2022
页数：6
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