Isoniazid-Induced Severe Hepatotoxicity: An Infrequent but Preventable Cause of Liver Failure in Children Treated for Latent Tuberculosis Infection

被引：5
|
作者：
Desrochers, Dan [1 ]
Gonzalez-Peralta, Regino P. [2 ,3 ]
McClenathan, Daniel T. [1 ]
Wilsey, Michael J., Jr. [1 ]
Haafiz, Allah [2 ,3 ]
机构：
[1] Univ S Florida, Coll Med, Dept Pediat, Tampa, FL 33620 USA
[2] Univ Florida, Coll Med, Div Pediat Gastroenterol Hepatol & Nutr, Pediatr Hepatol & Liver Transplantat, Gainesville, FL 32610 USA
[3] Shands Childrens Hosp, Gainesville, FL USA
来源：
CLINICAL MEDICINE INSIGHTS-PEDIATRICS | 2011年 / 5卷
关键词：
isoniazid; hepatotoxicity; latent tuberculosis infection;
D O I：
10.4137/CMPed.S6406
中图分类号：
R72 [儿科学];
学科分类号：
100202 ;
摘要：
Isoniazid (INH) monotherapy has gained widespread acceptance as an efficacious therapy for latent tuberculosis infection (LTBI) especially in low-prevalence settings. Although INH related hepatotoxicity is well recognized, progression to severe liver dysfunction requiring care at a transplant center remains unpredictable. We report the management of a five year-old girl who developed progressive liver failure due to INH prophylaxis. This highlights the potential severity of INH related hepatic injury and underscores the significance of vigilant clinical monitoring throughout the duration of the therapy in children.
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收藏
页码：9 / 13
页数：5
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