BOVINE CHROMAFFIN CELLS POSSES FTX-SENSITIVE CALCIUM CHANNELS

被引：58
|
作者：
GANDIA, L [1 ]
ALBILLOS, A [1 ]
GARCIA, AG [1 ]
机构：
[1] UNIV AUTONOMA MADRID,FAC MED,DEPT FARMACOL,E-28029 MADRID,SPAIN
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1993年 / 194卷 / 02期
关键词：
D O I：
10.1006/bbrc.1993.1874
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The effects of the synthetic analogue of the toxin from the venom of the funnel-web spider Agenelopsis aperta (sFTX) on whole-cell Ba2+ currents through Ca2+ channels were studied in cultured bovine chromaffin cells. sFTX selectively and reversibly blocked a significant component (55±3%) of the whole-cell IBa. Effects of sFTX were additive to those of ω-conotoxin GVIA, a selective blocker of N-type Ca2+ channels, and those of furnidipine, a novel dihydropyridine L-type Ca2+ channel blocker. We conclude that the cultured bovine chromaffin cells, in addition to N- and L-type Ca2+ channels, possess a P-type component in their whole-cell currents through their Ca2+ channels. © 1993 Academic Press, Inc.
引用
收藏
页码：671 / 676
页数：6
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