SALIVATORY RESPONSES TO CLASSICAL AND NONTRADITIONAL PARASYMPATHOLYTIC AGENTS IN HUMAN-SUBJECTS - CRITICAL COMMENTS

被引：2
|
作者：
LEVIN, SL [1 ]
机构：
[1] ST PETERSBURG PEDIAT SCH, NERVOUS DIS & NEUROSURG CLIN, ST PETERSBURG, USSR
来源：
JOURNAL OF CLINICAL PHARMACOLOGY | 1992年 / 32卷 / 11期
关键词：
D O I：
10.1002/j.1552-4604.1992.tb03804.x
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Both classical (atropine, scopolamine) and nontraditional (pirenzepine, telenzepine) cholinolytic agents themselves cause no salivation in human subjects. Ordinarily, they block salivation caused by pilocarpine. Conversely, they all stimulate intense salivatory response in the chronically denervated human parotid gland. The author presents critical comments on the concept that cholinolytic agents cause salivation by suppression of the mechanism of presynaptic autoinhibition. An alternative explanation of the initial cholinomimetic effect of cholinolytic agents is suggested.
引用
收藏
页码：1013 / 1022
页数：10
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