EFFECTS OF CHRONIC ETHANOL EXPOSURE ON CULTURED CEREBELLAR GRANULE CELLS

被引：8
|
作者：
OMODEOSALE, F [1 ]
PITTO, M [1 ]
MASSERINI, M [1 ]
PALESTINI, P [1 ]
机构：
[1] UNIV MILAN,SCH MED,DEPT MED CHEM & BIOCHEM,I-20122 MILAN,ITALY
来源：
MOLECULAR AND CHEMICAL NEUROPATHOLOGY | 1995年 / 26卷 / 02期
关键词：
D O I：
10.1007/BF02815010
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The aim of this study was to investigate the lipid content and composition of rat cerebellar granule cells grown in the presence of ethanol (40, 55, or 80 mM) during in vitro differentiation. Quantitative analyses showed no effects of 40 mM ethanol, whereas a significant increase of total cholesterol was observed at 55 mM. Cells exposed to the highest ethanol dose (80 mM) were characterized by a higher sialidase activity, and by the modification of the ganglioside pattern and phospholipid fatty acid composition. The observed modifications were accompanied by changes of membrane anisotropy fluorescence assessed by the fluorescent probe 1,6-diphenyl-1,3,5-hexatriene.
引用
收藏
页码：159 / 169
页数：11
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