RUTHENIUM RED SELECTIVELY INHIBITS EDEMA FORMATION AND INCREASED BLOOD-FLOW INDUCED BY CAPSAICIN IN RABBIT SKIN

被引：29
|
作者：
BUCKLEY, TL
BRAIN, SD
WILLIAMS, TJ
机构：
来源：
BRITISH JOURNAL OF PHARMACOLOGY | 1990年 / 99卷 / 01期
基金：
英国惠康基金;
关键词：
D O I：
10.1111/j.1476-5381.1990.tb14642.x
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
It has been suggested that ruthenium red has a selective inhibitory effect on capsaicin-induced nociceptor stimulation. We have investigated the effect of tuthenium red on oedema formation and vasodilatation induced by intradermal (i.d.) injection of capsaicin in the rabbit in vivo. Responses induced by capsaicin were inhibited by ruthenium red, but responses induced by bradykinin, N-formyl-methionyl-leucyl-phenyl-alanine (FMLP), platelet activating factor (PAF), histamine and calcitonin gene-related peptide (CGRP) were not affected. These results suggest that ruthenium red selectively inhibits capsaicin-induced local plasma protein leakage and vasodilatation in the rabbit skin microvasculature.
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页码：7 / 8
页数：2
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