Effects of Bisoprolol and Carvedilol on Left Ventricular Remodeling in Patients with Chronic Heart Failure

The purpose of the present research was to study the types of left ventricular (LV) remodeling in post-MI patients with chronic heart failure (CHF) and assess the impact of bisoprolol and carvedilol on LV remodeling. Material and Methods: The study included 217 post-MI patients with CHF between the ages of 38 and 60 (mean age 50.6 +/- 6.8 yrs) who were treated at the cardiology department of Tashkent Medical Academy. NYHA functional class (FC) of CHF was determined by the 6-minute walk test (6MWT). All the patients were divided into two groups. Group 1 consisted of 107 postMI patients with FC I-III, who received bisoprolol on the background of basic therapy during 6 months; Group 2 consisted of 110 post-MI patients with FC I-III, who received carvedilol on the background of basic therapy during 6 months. The mean daily dose of bisoprolol was 10 mg, and carvedilol. 25-50 mg. All patients underwent clinical examination, ECG, and echocardiography. Result: Reverse remodeling and improvement in left ventricular function was observed in both groups, with a slight advantage in the bisoprolol group. There was a decrease in the number of patients with prognostically unfavorable types of remodeling (eccentric and concentric LVH) and restoration of normal LV geometry.