SELECTIVITY OF ANTIMUSCARINIC COMPOUNDS FOR MUSCARINIC RECEPTORS OF HUMAN BRAIN AND HEART

被引：26
|
作者：
LARSON, EW
PFENNING, MA
RICHELSON, E
机构：
[1] MAYO CLIN JACKSONVILLE,4500 SAN PABLO RD,JACKSONVILLE,FL 32224
[2] MAYO CLIN & MAYO FDN,DEPT PHARMACOL,ROCHESTER,MN 55905
[3] MAYO CLIN & MAYO FDN,DEPT PSYCHIAT & PSYCHOL,ROCHESTER,MN 55905
来源：
PSYCHOPHARMACOLOGY | 1991年 / 103卷 / 02期
关键词：
PARKINSONISM DRUGS; PIRENZEPINE; M1-RECEPTOR AND M2-RECEPTOR;
D O I：
10.1007/BF02244197
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Seven antimuscarinic compounds, used mostly for the treatment of extrapyramidal problems, were tested in vitro in radioligand binding assays for evidence of selectivity for two different pharmacological subtypes of the human muscarinic receptor, M1, a predominant form in brain, and M2, a predominant form in heart. Although biperiden, scopolamine, procyclidine, and benztropine showed significant selectivity in the in vitro assays, it is likely that in clinical practice biperiden would be the drug of choice to avoid any antimuscarinic effects on the heart.
引用
收藏
页码：162 / 165
页数：4
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