Regression analysis of amino acid substitutions and factor IX activity in hemophilia B

被引：4
|
作者：
Utsunomiya, Makoto [1 ]
Sakamoto, Makoto [1 ]
Furutani, Hiroshi [1 ]
机构：
[1] Univ Miyazaki, Fac Engn, Miyazaki 8892192, Japan
来源：
ARTIFICIAL LIFE AND ROBOTICS | 2009年 / 13卷 / 02期
关键词：
Hemophilia B; Factor IX; Amino acid; PAM matrix; Regression analysis;
D O I：
10.1007/s10015-008-0600-y
中图分类号：
TP24 [机器人技术];
学科分类号：
080202 ; 1405 ;
摘要：
Hemophilia B is caused by a deficit or decreased activity of factor IX. Mutation in factor IX is made up of a majority of amino acid substitutions. We examined the relation between the activation level of factor IX and the category of amino acid substitution with regression analysis. As parameters, we used four physical-chemical parameters of amino acids and Dayhoff's PAM matrix. In addition, the average of the activation level with the same amino acid substitution was used for the analysis. We analyzed the relationship between variations containing cysteine or factor IX's seven regions and activity levels.
引用
收藏
页码：531 / 534
页数：4
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