CHRONIC ADMINISTRATION OF NICOTINE FAILS TO ALTER THE MPTP-INDUCED NEUROTOXICITY IN MICE

被引：16
|
作者：
FUNG, YK [1 ]
FISKE, LA [1 ]
LAU, YS [1 ]
机构：
[1] CREIGHTON UNIV,SCH MED,DEPT PHARMACOL,OMAHA,NE 68178
来源：
GENERAL PHARMACOLOGY | 1991年 / 22卷 / 04期
关键词：
D O I：
10.1016/0306-3623(91)90075-H
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
1. The effects of chronic (14 day) administration of nicotine on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) (15 mg/kg, s.c.)-induced neurotoxicity in C57BL/6 mice were examined. 2. Nicotine pretreatment failed to alter the deficit in locomotor activity and the reduction in striatal levels of dopamine produced by MPTP. 3. Our results do not support a therapeutic action of nicotine in a Parkinsonian animal model.
引用
收藏
页码：669 / 672
页数：4
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