AUTOANTIBODIES AGAINST A NOVEL DNA-BINDING PROTEIN - DNA-PROTEIN INTERACTION AS A REQUISITE FOR EXPRESSION OF ANTIGENIC REACTIVITY

被引：4
|
作者：
JUAREZ, C
VILA, JL
AGUSTI, M
GELPI, C
AMENGUAL, MJ
CARDONA, S
RODRIGUEZSANCHEZ, JL
机构：
[1] Department of Immunology, Hospital de Saunt Pau, Universitat Autonoma de Barcelona, Barcelona 08025
来源：
CLINICAL IMMUNOLOGY AND IMMUNOPATHOLOGY | 1994年 / 72卷 / 02期
关键词：
D O I：
10.1006/clin.1994.1138
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
A novel DNA-binding protein complex, the HB complex, has been characterized by means of autoantibodies. Three proteins of 9000, 7500, and 7000 Da constitute the HB complex. The 9000- and 7500-Da proteins are phosphorylated. Autoantibodies recognize the 7000-Da protein when it is bound to DNA. No reactivity against any protein was observed when the complex was dissociated from DNA. The three proteins are acidic (pI 5-6.2), and the complex was able to bind to synthetic double-stranded DNAs of different composition. (C) 1994 Academic Press, Inc.
引用
收藏
页码：248 / 254
页数：7
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