MECHANISM OF SCAVENGING EFFECTS OF (-)-EPIGALLOCATECHIN GALLATE ON ACTIVE OXYGEN-FREE RADICALS

被引：0

作者：

YANG, XQ ^{[1
]}

SHEN, SR ^{[1
]}

HOU, JW ^{[1
]}

ZHAO, BL ^{[1
]}

XIN, WJ ^{[1
]}

机构：

[1] ACAD SINICA,INST BIOPHYS,BEIJING 100101,PEOPLES R CHINA

来源：

ACTA PHARMACOLOGICA SINICA | 1994年 / 15卷 / 04期

关键词：

(-)-EPIGALLOCATECHIN; ELECTRON SPIN RESONANCE; CHEMILUMINESCENCE; FREE RADICAL SCAVENGERS;

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The concentration of 50% scavenging ratio (SC50) and the scavenging rate constants (k) and stiochiometric factor (n) were determined when (-)-epigallocatechin gallate [(-)-EGCG] scavenging superoxide anion free radical (O-2(-)) and hydroxyl radical (.OH). The mechanism of scavenging active free radicals of (-)-EGCG and the promotion of (-)-EGCG free radical and its structure were analyzed in vitro. Our results suggest that the centers of scavenging reaction of (-)-EGCG are B, D, and A cycles,and each (-)-EGCG traps six O-2(-) or OH. It is in accord with the value of stiochiometric factor n = 6.

引用

页码：350 / 353

页数：4

共 6 条

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