COMPLETE SEQUENCE OF THE RNA GENOME OF HUMAN RHINOVIRUS-16, A CLINICALLY USEFUL COMMON COLD VIRUS BELONGING TO THE ICAM-1 RECEPTOR GROUP

被引:41
|
作者
LEE, WM
WANG, WS
RUECKERT, RR
机构
[1] Institute for Molecular Virology, University of Wisconsin, Madison, 53706, WI
关键词
HUMAN RHINOVIRUS; SEQUENCE; COMMON COLD;
D O I
10.1007/BF01702661
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
We report here the complete nucleotide sequence and predicted polyprotein sequence of HeLa cell-adapted human rhinovirus 16 (HRV16). This virus is more suitable than human rhinovirus 14 (HRV14) for clinical studies, and its growth and physical properties are favorable for biochemical and crystallographic analysis. The complete message-sense RNA genome of HRV16 is composed of 7124 bases, not including the poly(A) tail. An open reading frame, extending from base 626 to 7084 predicts a polyprotein containing 2152 amino acid residues. Comparison with other rhinovirus sequences shows HRV16 is much more representative of human rhinoviruses than HRV14. No apparent relationship was found between receptor group and amino acid sequence in VP1, the capsid protein bearing the binding site for the intercullular adhesion molecule-1 (ICAM-1) in both HRV14 and HRV16.
引用
收藏
页码:177 / 181
页数:5
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