SEROTONIN AND IMPULSIVE/AGGRESSIVE BEHAVIOR IN COCAINE-DEPENDENT SUBJECTS

被引：39

作者：

MOELLER, FG

STEINBERG, JL

PETTY, F

FULTON, M

CHEREK, DR

KRAMER, G

GARVER, DL

机构：

[1] DEPT VET AFFAIRS MED CTR, DALLAS, TX USA

[2] UNIV TEXAS, SW MED SCH, DEPT PSYCHIAT, DALLAS, TX 75230 USA

[3] UNIV TEXAS, HLTH SCI CTR, DEPT PSYCHIAT, HOUSTON, TX USA

来源：

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY | 1994年 / 18卷 / 06期

关键词：

AGGRESSION; BUSPIRONE; COCAINE; SEROTONIN;

D O I：

10.1016/0278-5846(94)90128-7

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

1. 10 male cocaine dependent patients and 10 sex matched controls were administered several behavioral measures of aggression including the Buss-Durkee Hostility Inventory, and The Brown-Goodwin Life History of Aggression. 2. All subjects were also administered a buspirone neuroendocrine challenge as a measure of serotonin function. 3. The cocaine dependent subjects were significantly more aggressive than the controls. 4. There was a significant correlation between the growth hormone response to buspirone and behavioral measures of aggression in the cocaine dependent subjects, but not in the controls. 5. There was no difference in the overall growth hormone response between the controls and cocaine dependent subjects, possibly due to differences in metabolism of buspirone. 6. This study supports a role for serotonin in aggression in cocaine dependent subjects.

引用

页码：1027 / 1035

页数：9

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