CAFFEINE AND HUMAN CEREBRAL BLOOD-FLOW - A POSITRON EMISSION TOMOGRAPHY STUDY

被引：130
|
作者：
CAMERON, OG
MODELL, JG
HARIHARAN, M
机构：
[1] Department of Psychiatry, University of Michigan Medical Center
来源：
LIFE SCIENCES | 1990年 / 47卷 / 13期
关键词：
D O I：
10.1016/0024-3205(90)90174-P
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Positron emission tomography (PET) was used to quantify the effect of caffeine on whole brain and regional cerebral blood flow (CBF) in humans. A mean dose of 250 mg of caffeine produced approximately a 30% decrease in whole brain CBF; regional differences in caffeine effect were not observed. Pre-caffeine CBF strongly influenced the magnitude of the caffeine-induced decrease. Caffeine decreased paCO2 and increased systolic blood pressure significantly; the change in paCO2 did not account for the change in CBF. Smaller increases in diastolic blood pressure, heart rate, plasma epinephrine and norephinephrine, and subjectively reported anxiety were also observed. © 1990.
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页码：1141 / 1146
页数：6
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