COMPARISON OF THE EFFECTS OF THE IMMUNOSUPPRESSIVE AGENTS FK-506 AND CYCLOSPORINE-A ON RAT-KIDNEY MITOCHONDRIA

被引：38
|
作者：
HENKE, W
JUNG, K
机构：
[1] Research Division, the Urological Clinic, Medical Faculty (Charité), 10098 Berlin
来源：
BIOCHEMICAL PHARMACOLOGY | 1993年 / 46卷 / 05期
关键词：
D O I：
10.1016/0006-2952(93)90491-E
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Interactions of FK 506 with renal cortical mitochondria have been investigated by measuring respiration, ATP net uptake and Ca2+/P(i)-induced swelling. Both FK 506 and cyclosporin A (CsA) inhibit the succinate-supported state 3 and uncoupled respiration and are without effect on the glutamate/malate-supported state 3 and uncoupled respiration. FK 506, like CsA, inhibits net uptake of ATP, but, in contrast to CsA, is without effect on Ca2+/P(i)-induced swelling.
引用
收藏
页码：829 / 832
页数：4
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