SERINE PROTEASE INHIBITORS (SERPINS)

被引：15
|
作者：
SCHAPIRA, M
PATSTON, PA
机构：
来源：
TRENDS IN CARDIOVASCULAR MEDICINE | 1991年 / 1卷 / 04期
关键词：
D O I：
10.1016/1050-1738(91)90019-B
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Inhibition of serine proteases by serpins (serpin: serine protease inhibitor) is a key mechanism for the control of proteolysis in thrombosis, shock, and inflammation. The various members of the serpin gene superfamily (alpha-1-antitrypsin, ovalbumin, C1-inhibitor, antithrombin III, alpha-2-antiplasmin, type-1 plasminogen-activator inhibitor, and so forth) have many characteristics in common. In this article, we review the biochemistry and cell biology of serpins, and we discuss their clinical importance and therapeutic potential.
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页码：146 / 151
页数：6
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