Synthesis and Characterization of some new beta-Lactam Derivatives from Azo Sulphadiazine and its Biological Evaluation as Anticancer

In this work new Azo compound was synthesized through a diazo-coupling reaction (S1) (4-amino-N-(pyrimidine-2-yl)-3-( pyrimidine-2-yldiazenyl)benzene sulfonamide). The diazotization process of 2-aminopyrimidin with Sulphadiazine as coupling component was described, then Schiff bases[B1-B5] prepared from condensation of the free amino group in the azo compound with many aromatic aldehydes by using glacial Acetic acid as solvent. Cyclization of Shiff bases with Chloroacetyl chloride in the presence of tri ethyl amine give the corresponding beta-lactam derivatives [L1-L5]. All these compounds identified by( FTIR,H- 1-NMR, C-13-NMR) and follow by (TLC) and melting points of them.