The use of the term 'information' in the scientific vocabulary is recent, and its status as study object of the 'information science' - this one being also controversial, in that concerning its foundations, scope, boundaries and developments -even more recent. Starting from some definitions, emerging in different moments of de evolving process related to the meaning attributed by most brilliant scholars to the terms 'information' and 'information science', a persistent tendency to concentrate the interest of numerous studies in the practical developments of secular or even millenarian epistemes not perceived, can be observed, and consequently, they remain unveiled. It is in the study grounded on the representation and organization of information and knowledge that the foundations of the information science will be found. It is in a language (natural, oral, written artificial, etc.), or signal code of any kind, able to make perceivable the knowledge, to communicate, record, and transmit the information, which, in turn, by its interaction of new information with the individual or collective previous knowledge, generates a new knowledge. It is pure theory of knowledge at Web times, which makes it possible to replicate and distribute the information ad infinitum. And more important: the information, differently of energy, food or money, is not exhausted by use; inversely, it grows, is transformed and becomes richer. It follows, from all that, the great interest in information science as a catalyst of knowledge scientifically grounded.