Renal and Neurological Response with Eculizumab in a Patient with Transplant Associated Thrombotic Microangiopathy after Allogeneic Hematopoietic Progenitor Cell Transplantation

被引：10
|
作者：
Sevindik, Omur Gokmen [1 ]
Alacacioglu, Inci [1 ]
Katgi, Abdullah [1 ]
Solmaz, Serife Medeni [1 ]
Acar, Celal [1 ]
Piskin, Ozden [1 ]
Ozcan, Mehmet Ali [1 ]
Demirkan, Fatih [1 ]
Undar, Bulent [1 ]
Ozsan, Guner Hayri [1 ]
机构：
[1] Dokuz Eylul Univ, Dept Hematol, TR-35340 Izmir, Turkey
来源：
CASE REPORTS IN HEMATOLOGY | 2015年 / 2015卷
关键词：
D O I：
10.1155/2015/425410
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Transplantation-associated thrombotic microangiopathy (TA-TMA) is a challenge after allogeneic hematopoietic progenitor cell transplantation, considering the diagnostic uncertainties and lack of established treatment. We report a 43-year-old male patient who was diagnosed as TA-TMA after allogeneic progenitor cell transplantation for a progressive ALK negative anaplastic large cell lymphoma and responded to eculizumab with dramatically improving neurological status and renal function. Rapid neurological and renal recovery achieved after eculizumab could support a possible relationship between complement activation and TA-TMA. Eculizumab should be a reasonable treatment approach in patients with TA-TMA after allogeneic hematopoietic progenitor cell transplantation.
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页数：4
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