FORMULATION AND EVALUATION OF HYDROCHLOROTHIAZIDE AND RAMIPRIL MOUTH DISSOLVING TABLET USING DIFFERENT SUPERDISINTEGRANTS

The purpose of this research was to develop mouth dissolve tablets of Hydrochlorothiazide and Ramipril, were prepared by direct compression technique. Ramipril is an Angiotensin Converting Enzyme (ACE) inhibitor. It is an inactive prodrug that is converted to ramiprilat in the liver, the main site of activation, and kidneys. Thiazides such as hydrochlorothiazide promote water loss from the body (diuretics). They inhibit Sodium and Chlorine (Na+ and Cl-) reabsorption from the distal convoluted tubules in the kidneys. The tablets were prepared using microcrystalline cellulose and dicalcium phosphate as diluents along with three different levels of disintegrant. The superdisintegrant used in this study were CCS and Maize Starch. The tablets were evaluated for weight variation, hardness, friability, wetting time, water absorption ratio, disintegration time (DT) and dissolution study. Formulation prepared with 30% of CCS showed Disintegration time of 20seconds in vitro. Also the hardness, friability, dissolution rate of prepared tablets (batch F4) was found to be acceptable according to standard limits.