ISOLATION OF SUBSTANCES FROM GLOSSY PRIVET (LIGUSTRUM-LUCIDUM AIT) INHIBITING THE MUTAGENICITY OF BENZO[A]PYRENE IN BACTERIA

被引：38
|
作者：
NIIKAWA, M
HAYASHI, H
SATO, T
NAGASE, H
KITO, H
机构：
[1] Department of Public Health, Gifu Pharmaceutical University, Gifu City, Gifu, 502, 5-6-1, Mitahora-higashi
来源：
MUTATION RESEARCH | 1993年 / 319卷 / 01期
关键词：
GLOSSY PRIVET (LIGUSTRUM-LUCIDUM AIT); OLEANOLIC ACID; URSOLIC ACID; NUEZHENIDE; INHIBITOR OF MUTAGENICITY; SALMONELLA-TYPHIMURIUM-TA98; BENZO[A]PYRENE;
D O I：
10.1016/0165-1218(93)90025-9
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Methanol and hot-water extracts of glossy privet (Ligustrum lucidum Ait.) inhibited the mutagenic activity of benzo[a]pyrene in Salmonella typhimurium TA98 with S9 mix. The methanol extract was fractionated with ether and n-hexane. As the active components, oleanolic and ursolic acids were isolated, which were soluble in ether and insoluble in n-hexane. The hot-water extract was fractionated to water, 60% and 100% methanol fractions. Nuezhenide was isolated from the 60% methanol fraction as the active component.
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页码：1 / 9
页数：9
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