CIRCULATING INTERCELLULAR-ADHESION MOLECULE-1 LEVELS AND NEUTROPHIL ADHESION IN STROKE

被引：45
|
作者：
CLARK, WM [1 ]
COULL, BM [1 ]
BRILEY, DP [1 ]
MAINOLFI, E [1 ]
ROTHLEIN, R [1 ]
机构：
[1] BOEHRINGER INGELHEIM PHARMACEUT,DEPT IMMUNOL,RIDGEFIELD,CT
来源：
JOURNAL OF NEUROIMMUNOLOGY | 1993年 / 44卷 / 01期
关键词：
INTERCELLULAR ADHESION MOLECULES; STROKE; LEUKOCYTES; CELL ADHESION;
D O I：
10.1016/0165-5728(93)90275-4
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
To examine whether changes in leukocyte adhesion properties occur during stroke, we measured circulating serum intercellular adhesion molecule 1 (cICAM-1) levels and neutrophil adhesion in acute stroke, patients at high risk of stroke, and in matched controls. Levels of cICAM-1 were significantly lower in the stroke group (186.2 +/- 15.6 ng ml-1) compared to controls (257.7 +/- 24.8) and risks (257.7 +/- 16.5). Neutrophil adhesion was significantLy higher in the stroke group (23.6 +/- 4.3%; n = 14) compared to controls (9.7 +/- 2.3%; n = 12) and risks (12.7 +/- 2.5%; n = 13). These data suggest that changes in leukocyte adhesion dynamics are occurring in acute stroke.
引用
收藏
页码：123 / 126
页数：4
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