METABOLIC CONTROL-THEORY - A GRAPH-THEORETIC APPROACH

被引：0

作者：

SEN, AK ^{[1
]}

机构：

[1] CALTECH, DEPT CHEM ENGN, PASADENA, CA 91125 USA

来源：

BIOMEDICA BIOCHIMICA ACTA | 1990年 / 49卷 / 8-9期

关键词：

D O I：

暂无

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The regulatory properties of metabolic pathways are investigated using a graph-theoretic approach. Applying concepts from classical graph theory, analytical expressions are derived for the flux control coefficients of a linear pathway subject to feedback inhibition. It is shown that the relative importance of the various enzymes in the control of flux can be easily established with the aid of this graphical procedure. Another advantage of this technique is that it can be implemented in a step-by-step fashion for simplifying the pathway structure. The graph-theoretic method can also be used for studying the cause-effect relationships of the individual enzymes in a given pathway.

引用

页码：817 / 827

页数：11

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