REDOX-CONTROLLED BERGMAN CYCLOAROMATIZATIONS - DESIGNED ENEDIYNES WITH DNA-CLEAVING PROPERTIES AND ANTITUMOR-ACTIVITY

被引：104
|
作者：
NICOLAOU, KC [1 ]
LIU, A [1 ]
ZENG, Z [1 ]
MCCOMB, S [1 ]
机构：
[1] UNIV CALIF SAN DIEGO, DEPT CHEM, LA JOLLA, CA 92093 USA
来源：
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 1992年 / 114卷 / 24期
关键词：
D O I：
10.1021/ja00050a006
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Enediynes 7 and 9 were designed for their potential to act as radical-generating species upon oxidation to the corresponding quinone. Their synthesis entailed a chromium-nickel-mediated ring closure of iodo aldehyde 6. Investigations with these molecules and their derivatives 8 and 10 demonstrated the anticipated acceleration of the Bergman cycloaromatization of the oxidized species as compared to the reduced compounds and potent DNA-cleaving and antitumor properties.
引用
收藏
页码：9279 / 9282
页数：4
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