MORPHINE-CONDITIONED ANALGESIA USING A TASTE CUE - DISSOCIATION OF TASTE-AVERSION AND ANALGESIA

被引:29
|
作者
BARDO, MT
VALONE, JM
机构
[1] Department of Psychology, University of Kentucky, Lexington, 40506, KY
关键词
MORPHINE; LITHIUM; CONDITIONED TASTE; ANALGESIA; CONDITIONED ANALGESIA;
D O I
10.1007/BF02244848
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The present study examined the ability of a taste cue to serve as a conditioned stimulus (CS) for conditioning the analgesic effect of morphine. Rats were given three pairings of a taste CS with a morphine unconditioned stimulus (US). As expected, there was a decrease in CS intake across repeated pairings, indicating that a conditioned taste aversion was obtained. More important, presentation of the CS alone also increased paw-lick latencies on a hot plate test (either 50 degrees C or 54 degrees C hot plate), suggesting that an analgesic conditioned response (CR) was obtained. The dose of morphine required to produce conditioned analgesia was higher than the dose of morphine required to produce conditioned taste aversion. Using 15 mg/kg morphine, however, both conditioned taste aversion and conditioned analgesia were present when the morphine US was given immediately following CS intake, but not when given 6h following CS intake. In contrast to morphine, pairing a taste CS with lithium produced a conditioned taste aversion without any conditioned analgesic response. These results indicate that acquisition of an analgesic CR is not the result of stress induced by an aversion to the taste CS.
引用
收藏
页码:269 / 274
页数:6
相关论文
共 50 条