Funoran-Containing Xylitol Gum and Tablets Inhibit Adherence of Oral Streptococci

The aim of this study was to evaluate inhibition of adherence of oral streptococci by addition of funoran to xylitol-containing chewing gum or tablets. The inhibitory effect by addition of funoran on adherence was evaluated by scintillation counting using H-3-labeled oral streptococci and saliva-coated hydroxyapatite beads. In samples containing more than 0.1% funoran, the number of attached bacteria was significantly reduced in all tested microorganisms compared with funoran-free samples. This reduction in adherence was also observed by scanning electron microscopy. The results indicate that addition of funoran to xylitol chewing gum or tablets inhibits colonization by oral streptococci, including Streptococcus mutans.