VIGABATRIN AS AN ANTICONVULSANT AGAINST PENTYLENETETRAZOL SEIZURES

被引：27
|
作者：
SAYIN, U [1 ]
CENGIZ, S [1 ]
ALTUG, T [1 ]
机构：
[1] ISTANBUL FAC MED,INST BIOL & MED RES,ISTANBUL 34390,TURKEY
来源：
PHARMACOLOGICAL RESEARCH | 1993年 / 28卷 / 04期
关键词：
GAMMA VINYL GABA; PENTYLENETETRAZOL; SODIUM VALPROATE; ANTICONVULSIVE; EPILEPSY; GABA;
D O I：
10.1006/phrs.1993.1134
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The anticonvulsant effects of gamma vinyl GABA (GVG) were investigated against pentylenetetrazol (PTZ) seizures, while sodium valproate (VP) was used as positive control. At 1000 and 1500 mg kg-1 GVG was found to decrease seizure intensity either in 4 or 24 h, as effectively as VP. At 2000 mg kg-1 GVG was found to be almost ineffective. At both doses and both time spans of drug action, seizure latency was prolonged, compared to controls and VP group. © 1993 The Italian Pharmacological Society.
引用
收藏
页码：325 / 331
页数：7
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