PHARMACOLOGY OF GR203040, A POTENT AND SELECTIVE NONPEPTIDE TACHYKININ NK1 RECEPTOR ANTAGONIST

被引:0
|
作者
BEATTIE, DT
CONNER, HE
HAWCOCK, AB
PERREN, MJ
WARD, P
机构
[1] GLAXO RES & DEV LTD,DEPT PHARMACOL,STEVENAGE SG1 2NY,HERTS,ENGLAND
[2] GLAXO RES & DEV LTD,DEPT MED CHEM,STEVENAGE SG1 2NY,HERTS,ENGLAND
关键词
D O I
暂无
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
引用
收藏
页码:P37 / P37
页数:1
相关论文
共 50 条
  • [1] The pharmacology of GR203040, a novel, potent and selective non-peptide tachykinin NK1 receptor antagonist
    Beattie, DT
    Beresford, IJM
    Connor, HE
    Marshall, FH
    Hawcock, AB
    Hagan, RM
    Bowers, J
    Birch, PJ
    Ward, P
    BRITISH JOURNAL OF PHARMACOLOGY, 1995, 116 (08) : 3149 - 3157
  • [3] The broad-spectrum anti-emetic activity of the novel non-peptide tachykinin NK1 receptor antagonist GR203040
    Gardner, CJ
    Twissell, DJ
    Dale, TJ
    Gale, JD
    Jordan, CC
    Kilpatrick, GJ
    Bountra, C
    Ward, P
    BRITISH JOURNAL OF PHARMACOLOGY, 1995, 116 (08) : 3158 - 3163
  • [4] PHARMACOLOGY OF CP-99,994 - A NONPEPTIDE ANTAGONIST OF THE TACHYKININ NK1 RECEPTOR
    MCLEAN, S
    GANONG, A
    SEYMOUR, PA
    SNIDER, RM
    DESAI, MC
    ROSEN, T
    BRYCE, DK
    LONGO, KP
    REYNOLDS, LS
    ROBINSON, G
    SCHMIDT, AW
    SIOK, C
    HEYM, J
    REGULATORY PEPTIDES, 1992, : S120 - S120
  • [5] The NK1 antagonist GR203040 inhibits cyclophosphamide-induced damage in the rat and ferret bladder
    Alfieri, A
    Gardner, C
    GENERAL PHARMACOLOGY, 1997, 29 (02): : 245 - 250
  • [6] Pharmacology of the peptidomimetic, MEN 11149, a new potent, selective and orally effective tachykinin NK1 receptor antagonist
    Cirillo, R
    Astolfi, M
    Conte, B
    Lopez, G
    Parlani, M
    Terracciano, R
    Fincham, CI
    Manzini, S
    EUROPEAN JOURNAL OF PHARMACOLOGY, 1998, 341 (2-3) : 201 - 209
  • [7] Nonpeptide antagonists of the NK1 tachykinin receptor
    McLean, S
    MEDICINAL RESEARCH REVIEWS, 1996, 16 (04) : 297 - 317
  • [8] Potent nonpeptide antagonist of the substance P (NK1) receptor
    Snider, R.M.
    Constantine, J.W.
    Lowe, J.A. III
    Longo, K.P.
    Lebel, W.S.
    Woody, H.A.
    Drozda, S.E.
    Desai, M.C.
    Vinick, F.J.
    Science, 1991, 251 (4992)
  • [9] MEN 11149, a potent antagonist of the tachykinin NK1 receptor
    Astolfi, M
    Parlani, M
    Lopez, G
    Conte, B
    Cirillo, R
    Fincham, CI
    Terracciano, R
    Manzini, S
    BRITISH JOURNAL OF PHARMACOLOGY, 1997, 120 : P202 - P202
  • [10] Effects of GR203040, an NK1 antagonist, on radiation- and cisplatin-induced tissue damage in the ferret
    Alfieri, AB
    Gardner, CJ
    GENERAL PHARMACOLOGY-THE VASCULAR SYSTEM, 1998, 31 (05): : 741 - 746