DIAZEPAM PRETREATMENT ATTENUATES THE SUPPRESSANT EFFECT OF INTRAPERITONEAL ADMINISTRATION OF CHOLECYSTOKININ (CCK) ON FOOD-INTAKE IN FOOD-DEPRIVED RATS

被引：0
|
作者：
EBENEZER, IS
WARREN, D
机构：
来源：
METHODS AND FINDINGS IN EXPERIMENTAL AND CLINICAL PHARMACOLOGY | 1993年 / 15卷 / 09期
关键词：
BENZODIAZEPINES; DIAZEPAM; CHOLECYSTOKININ; FOOD INTAKE;
D O I：
暂无
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The aim of the present study was to determine whether diazepam pretreatment could prevent the inhibitory effect of systemically administered CCK on food intake in rats. Diazepam (0.5 and 1 mg/kg) administered subcutaneously 10 min prior to intraperitoneal injection of CCK (5 mcg/kg) attenuated the suppressant effect of the peptide on feeding in a dose-related manner Both doses of diazepam had no effect on food intake when administered alone. These results suggest that the benzodiazepines interact with CCK by some unknown mechanism to modify feeding behavior.
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页码：659 / 663
页数：5
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