Mutagenicity of cytostatic drugs in a bacterial system .1. Ames test

被引：17
|
作者：
Marhan, J
机构：
[1] Research Institute of Pharmacy and Biochemistry Co. (VÚFB), Pardubice-Rosice
来源：
FOLIA MICROBIOLOGICA | 1995年 / 40卷 / 05期
关键词：
D O I：
10.1007/BF02814722
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
A set of nine cytostatic drugs were tested in the standard plate incorporation method of Ames reversion test using four Salmonella typhimurium his strains. Six of them were classical and commonly used cytostatics, three (cloturin, butocin and oracin) are at different stages of development. The results showed 6-mercaptopurine, cloturin, adriamycin, mitoxantron, cyclophosphamide and lomustine to be mutagenic; butocin, oracin and tris(2-chloroethyl)amine were negative in this test.
引用
收藏
页码：457 / 461
页数：5
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