MECHANISMS OF IMMUNE-MEDIATED MYOCYTE INJURY

被引:115
|
作者
BARRY, WH [1 ]
机构
[1] UNIV UTAH,SCH MED,DEPT MED,DIV CARDIOL,SALT LAKE CITY,UT 84132
关键词
D O I
10.1161/01.CIR.89.5.2421
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Much progress has been made in defining the mechanisms by which altered systolic and diastolic function of the heart may be produced by components of the immune system activated during allograft rejection and myocarditis and in patients with dilated cardiomyopathy. It is clear that injury of the vascular bed can occur via both humoral and cellular mediators and probably accounts for the acute alterations in ventricular compliance that occur during allograft rejection, as well as the accelerated development of graft atherosclerosis. Altered myocyte function and lysis can be produced by CTL in vitro, but the importance of this injury process in vivo remains uncertain. Other cells present in the inflammatory infiltrate can also affect myocyte function and survival. Neutrophils may cause lysis of myocytes, and cytokines produced by infiltrating macrophages and HTL may reach a sufficient concentration in the interstitial microenvironment to decrease myocyte catecholamine responsiveness and/or directly depress myocyte contractility. Humoral antibodies to myocyte cell surface antigens may cause cell damage by an antibody-dependent cytotoxic cell mechanism or by directly binding to and altering sarcolemmal receptor and/or ion channel function. Further elucidation of the extent of involvement of these different mechanisms in specific clinical settings may provide a basis for improved therapy of immune-mediated cardiac injury and dysfunction.
引用
收藏
页码:2421 / 2432
页数:12
相关论文
共 50 条
  • [1] Mechanisms of Immune-Mediated Liver Injury
    Adams, David H.
    Ju, Cynthia
    Ramaiah, Shashi K.
    Uetrecht, Jack
    Jaeschke, Hartmut
    [J]. TOXICOLOGICAL SCIENCES, 2010, 115 (02) : 307 - 321
  • [2] Liver fibrosis: mechanisms of immune-mediated liver injury
    Ruonan Xu
    Zheng Zhang
    Fu-Sheng Wang
    [J]. Cellular & Molecular Immunology, 2012, 9 : 296 - 301
  • [3] Liver fibrosis: mechanisms of immune-mediated liver injury
    Xu, Ruonan
    Zhang, Zheng
    Wang, Fu-Sheng
    [J]. CELLULAR & MOLECULAR IMMUNOLOGY, 2012, 9 (04) : 296 - 301
  • [4] Acute liver failure: mechanisms of immune-mediated liver injury
    Wu, Zeguang
    Han, Meifang
    Chen, Tao
    Yan, Weiming
    Ning, Qin
    [J]. LIVER INTERNATIONAL, 2010, 30 (06) : 782 - 794
  • [5] IMMUNE-MEDIATED OLIGODENDROCYTE INJURY
    COMPSTON, DAS
    SCOLDING, NJ
    [J]. ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 1991, 633 : 196 - 204
  • [6] Immune-mediated liver injury
    Herkel, J
    Schuchmann, M
    Tiegs, G
    Lohse, AW
    [J]. JOURNAL OF HEPATOLOGY, 2005, 42 (06) : 920 - 923
  • [7] Immune-mediated liver injury
    Eksteen, Bertus
    Afford, Simon C.
    Wigmore, Stephen J.
    Holt, Andrew P.
    Adams, David H.
    [J]. SEMINARS IN LIVER DISEASE, 2007, 27 (04) : 351 - 366
  • [8] Immune-mediated lung injury
    Karampitsakos, Theodoros
    Spagnolo, Paolo
    Tzouvelekis, Argyris
    [J]. FRONTIERS IN MEDICINE, 2023, 10
  • [9] Mechanisms of immune-mediated demyelination in the CNS
    Antel, J. P.
    [J]. JOURNAL OF NEUROIMMUNOLOGY, 2006, 178 : 11 - 12
  • [10] Pathology of Immune-Mediated Liver Injury
    Dienes, Hans-Peter
    Drebber, Uta
    [J]. DIGESTIVE DISEASES, 2010, 28 (01) : 57 - 62