1,1'-ETHYLIDENEBIS(L-TRYPTOPHAN), STRUCTURE DETERMINATION OF CONTAMINANT-97 - IMPLICATED IN THE EOSINOPHILIA-MYALGIA-SYNDROME (EMS)

被引：56

作者：

SMITH, MJ

MAZZOLA, EP

FARRELL, TJ

SPHON, JA

PAGE, SW

ASHLEY, D

SIRIMANNE, SR

HILL, RH

NEEDHAM, LL

机构：

[1] US FDA, CTR FOOD SAFETY & APPL NUTR, FOOD FORMULAT BRANCH, WASHINGTON, DC 20204 USA

[2] CTR DIS CONTROL, CTR ENVIRONM HLTH & INJURY CONTROL, TOXICOL BRANCH, ATLANTA, GA 30333 USA

来源：

TETRAHEDRON LETTERS | 1991年 / 32卷 / 08期

关键词：

D O I：

10.1016/S0040-4039(00)74469-8

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The condensation of tryptophan and acetaldehyde affords a bisindolylaminal of tryptophan which is indistinguishable from contaminant "97". The formation and decomposition of aminals is addressed in light of epidemiological evidence linking them to a recent outbreak of EMS.

引用

页码：991 / 994

页数：4

共 50 条

[1] STUDIES WITH 1,1'-ETHYLIDENEBIS(TRYPTOPHAN), A CONTAMINANT ASSOCIATED WITH L-TRYPTOPHAN IMPLICATED IN THE EOSINOPHILIA-MYALGIA-SYNDROME
SIDRANSKY, H
VERNEY, E
COSGROVE, JW
LATHAM, PS
MAYENO, AN
[J]. TOXICOLOGY AND APPLIED PHARMACOLOGY, 1994, 126 (01) : 108 - 113
[2] A MURINE MODEL OF THE EOSINOPHILIA-MYALGIA-SYNDROME INDUCED BY 1,1'-ETHYLIDENEBIS(L-TRYPTOPHAN)
SILVER, RM
LUDWICKA, A
HAMPTON, M
OHBA, T
BINGEL, SA
SMITH, T
HARLEY, RA
MAIZE, J
HEYES, MP
[J]. JOURNAL OF CLINICAL INVESTIGATION, 1994, 93 (04): : 1473 - 1480
[3] IDENTIFICATION OF DECOMPOSITION PRODUCTS OF 1,1'-ETHYLIDENEBIS [L-TRYPTOPHAN], A COMPOUND ASSOCIATED WITH EOSINOPHILIA-MYALGIA-SYNDROME
DRISKELL, WJ
ASHLEY, DL
GRAINGER, J
SIRIMANNE, SR
MAZZOLA, EP
PAGE, SW
NEEDHAM, LL
HILL, RH
[J]. BULLETIN OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY, 1992, 48 (05) : 679 - 687
[4] PATHOLOGICAL-CHANGES IN RAT MUSCLE INDUCED BY 1,1'-ETHYLEDENEBIS(TRYPTOPHAN), AN L-TRYPTOPHAN CONTAMINANT IMPLICATED IN THE EOSINOPHILIA-MYALGIA-SYNDROME
EMSLIESMITH, AM
MAYENO, AN
NAKANO, S
GLEICH, GJ
ENGEL, AG
[J]. ANNALS OF NEUROLOGY, 1992, 32 (02) : 253 - 254
[5] EOSINOPHILIA-MYALGIA-SYNDROME AND L-TRYPTOPHAN
GOLDEN, RL
[J]. NEW YORK STATE JOURNAL OF MEDICINE, 1990, 90 (10) : 512 - 513
[6] L-TRYPTOPHAN AND EOSINOPHILIA-MYALGIA-SYNDROME
SHAPIRO, S
[J]. LANCET, 1994, 343 (8904): : 1035 - 1036
[7] L-TRYPTOPHAN - EOSINOPHILIA-MYALGIA-SYNDROME
DARCY, PF
[J]. ADVERSE DRUG REACTIONS AND TOXICOLOGICAL REVIEWS, 1995, 14 (01) : 37 - 43
[8] L-TRYPTOPHAN AND EOSINOPHILIA-MYALGIA-SYNDROME
MITCHELL, N
[J]. MEDICAL JOURNAL OF AUSTRALIA, 1993, 158 (05) : 363 - 364
[9] L-TRYPTOPHAN AND EOSINOPHILIA-MYALGIA-SYNDROME
SHAPIRO, S
[J]. LANCET, 1994, 344 (8925): : 817 - 818
[10] PRODUCTION OF POLYCLONAL ANTIBODIES AGAINST 1,1'-ETHYLIDEN BIS[L-TRYPTOPHAN] (EBT), A POTENTIAL CONTAMINANT CAUSING EOSINOPHILIA-MYALGIA-SYNDROME (EMS)
KURIHARA, N
YANAGISAWA, H
JIN, Z
WADA, O
[J]. TOXICOLOGY LETTERS, 1993, 66 (03) : 231 - 236

← 1 2 3 4 5 →