STIMULATION AND INHIBITION OF INTERFERON-BETA PRODUCTION OF HUMAN-DIPLOID FIBROBLASTS BY FOODSTUFFS

被引：18
|
作者：
YAMADA, K [1 ]
MATSUMURA, K [1 ]
SUZAKI, M [1 ]
SHIRAHATA, S [1 ]
MURAKAMI, H [1 ]
机构：
[1] KYUSHU UNIV 4609,FAC AGR,DEPT FOOD SCI & TECHNOL,6-10-1 HAKOZAKI,HIGASHI KU,FUKUOKA 812,JAPAN
来源：
AGRICULTURAL AND BIOLOGICAL CHEMISTRY | 1991年 / 55卷 / 03期
关键词：
D O I：
10.1080/00021369.1991.10870664
中图分类号：
S3 [农学（农艺学）];
学科分类号：
0901 ;
摘要：
We screened for foodstuffs affecting interferon-beta (IFN-beta) production of human foreskin diploid fibroblasts, in the presence of poly I.poly C, cycloheximide, and actinomycin D. alpha- and beta-caseins stimulated IFN-beta production dose-dependently, but kappa-casein inhibited it. Of the two chymosin fragments of kappa-casein, glycomacropeptide was an inhibitor but p-kappa-casein was not. beta-lactoglobulin stimulated IFN-beta production weakly, but lactoferrin inhibited it strongly. It was also shown that serum contained some factors inhibiting IFN-beta induction and stimulating its production.
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页码：829 / 832
页数：4
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