S-ADENOSYL-L-METHIONINE NORMALIZES P300 LATENCY IN PATIENTS WITH MAJOR DEPRESSION - A PRELIMINARY-REPORT

被引：8

作者：

TORTA, R ^{[1
]}

BORIO, R ^{[1
]}

CICOLIN, A ^{[1
]}

VIGHETTI, S ^{[1
]}

RAVIZZA, L ^{[1
]}

机构：

[1] UNIV TURIN, INST CLIN NEUROL, I-10126 TURIN, ITALY

来源：

CURRENT THERAPEUTIC RESEARCH-CLINICAL AND EXPERIMENTAL | 1994年 / 55卷 / 07期

关键词：

D O I：

10.1016/S0011-393X(05)80780-5

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Ten patients with major depression diagnosed according to the American Psychiatric Association's Diagnostic and Statistical Manual of Mental Disorders, third edition, revised, criteria and 10 healthy volunteers were enrolled in a study to investigate the effects of S-adenosyl-L-methionine (SAMe) on two late components of brain event-related potentials, P300 and N100. Psychomotor retardation in depressed patients is marked by increased P300 latency. SAMe 400 mg administered intravenously, daily for 5 days in patients with major depression as compared with healthy volunteers restored P300 latency to normal. N100 levels, which were similar in both groups before SAMe administration, were apparently unaffected by treatment.

引用

页码：864 / 874

页数：11

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