EFFECT OF FAMOTIDINE ON RENAL-TRANSPLANT PATIENTS TREATED WITH CYCLOSPORINE-A

被引：1
|
作者：
MOREL, D
BANNWARTH, B
VINCON, G
PENOUIL, F
ELOUAERBLANC, L
APARICIO, M
POTAUX, L
机构：
[1] LABS MERCK SHARP & DOHME CHIBRET,F-75008 PARIS,FRANCE
[2] UNIV BORDEAUX 2,CTR PHARMACOL,F-33076 BORDEAUX,FRANCE
来源：
FUNDAMENTAL & CLINICAL PHARMACOLOGY | 1993年 / 7卷 / 3-4期
关键词：
CYCLOSPORINE-A; FAMOTIDINE; PHARMACOKINETICS; DRUG INTERACTION; RENAL TRANSPLANTATION;
D O I：
10.1111/j.1472-8206.1993.tb00231.x
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The influence of a 7-day course of 40 mg famotidine administered orally on the pharmacokinetics of ciclosporine A at steady-state has been investigated in 10 renal transplant patients. Famotidine did not appear to significantly alter the pharmacokinetics of ciclosporine A. This might be ascribed to the limited potential of famotidine for inhibiting microsomal enzyme function. Moreover, plasma creatinine concentrations and creatinine clearance remained stable. Our results suggest that famotidine has no noticeable interaction with ciclosporine A.
引用
收藏
页码：167 / 170
页数：4
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