ROLE OF DRUG CONCENTRATION, DURATION OF EXPOSURE, AND ENDOGENOUS METABOLITES IN DETERMINING METHOTREXATE CYTOTOXICITY

被引:0
|
作者
PINEDO, HM
CHABNER, BA
机构
[1] NCI,DIV CANC TREATMENT,CLIN PHARMACOL BRANCH,PROGRAM CLIN ONCOL,BETHESDA,MD 20014
[2] STATE UNIV UTRECHT HOSP,DEPT INTERNAL MED,ONCOL UNIT,UTRECHT,NETHERLANDS
来源
CANCER TREATMENT REPORTS | 1977年 / 61卷 / 04期
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中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
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页码:709 / 715
页数:7
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  • [1] IMPORTANCE OF METHOTREXATE PLASMA CONCENTRATION [MTX]P AND DURATION OF EXPOSURE IN DETERMINING MARROW TOXICITY DURING CONTINUOUS INFUSION
    PINEDO, HM
    ZAHARKO, DS
    BULL, JM
    YOUNG, RC
    CHABNER, BA
    [J]. PROCEEDINGS OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH, 1976, 17 (MAR): : 104 - 104
  • [2] ROLE OF HYPOXANTHINE AND THYMIDINE IN DETERMINING METHOTREXATE PLUS DIPYRIDAMOLE CYTOTOXICITY
    CHAN, TCK
    HOWELL, SB
    [J]. EUROPEAN JOURNAL OF CANCER, 1990, 26 (08) : 907 - 911
  • [3] ROLE OF CULTURE CONDITIONS AND EXPOSURE DURATION IN DETERMINING SENSITIVITY OF HUMAN-BONE MARROW PROGENITOR CELLS TO METHOTREXATE
    UMBACH, GE
    SPITZER, G
    AJANI, JA
    HUG, V
    THAMES, H
    RUDOLPH, FB
    DREWINKO, B
    [J]. JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY, 1986, 111 (03) : 273 - 276
  • [4] RELATIVE CONTRIBUTION OF DRUG CONCENTRATION AND DURATION OF EXPOSURE TO MOUSE BONE-MARROW TOXICITY DURING CONTINUOUS METHOTREXATE INFUSION
    PINEDO, HM
    ZAHARKO, DS
    BULL, J
    CHABNER, BA
    [J]. CANCER RESEARCH, 1977, 37 (02) : 445 - 450
  • [5] EFFECTS OF PROLONGED EXPOSURE TO CISPLATIN ON CYTOTOXICITY AND INTRACELLULAR DRUG CONCENTRATION
    TROGER, V
    FISCHEL, JL
    FORMENTO, P
    GIOANNI, J
    MILANO, G
    [J]. EUROPEAN JOURNAL OF CANCER, 1992, 28A (01) : 82 - 86
  • [6] The postantibiotic effect of imipenem: Relationship with drug concentration, duration of exposure, and MIC
    Munckhof, WJ
    Olden, D
    Turnidge, JD
    [J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1997, 41 (08) : 1735 - 1737
  • [7] INTRAVESICAL CHEMOTHERAPY - A STUDY OF THE RELATIONSHIPS BETWEEN DRUG CONCENTRATION, PERIOD OF EXPOSURE AND CYTOTOXICITY
    MASTERS, JRW
    WALKER, CM
    PARRIS, CN
    ENGLISH, P
    [J]. JOURNAL OF UROLOGY, 1986, 135 (04): : A285 - A285
  • [8] Interaction of exposure concentration and duration in determining acute toxic effects of sarin vapor in rats
    Mioduszewski, R
    Manthei, J
    Way, R
    Burnett, D
    Gaviola, B
    Muse, W
    Thomson, S
    Sommerville, D
    Crosier, R
    [J]. TOXICOLOGICAL SCIENCES, 2002, 66 (02) : 176 - 184
  • [9] Interaction of exposure concentration and duration in determining the apoptosis of testis in rats after cigarette smoke inhalation
    He, Lijuan
    Gong, Haiyan
    Zhang, Jing
    Zhong, Chunxue
    Huang, Yunfei
    Zhang, Chen
    Ashraf, Muhammad Aqeel
    [J]. SAUDI JOURNAL OF BIOLOGICAL SCIENCES, 2016, 23 (04) : 531 - 541
  • [10] Capping Methotrexate α-Carboxyl Groups Enhances Systemic Exposure and Retains the Cytotoxicity of Drug Conjugated PEGylated Polylysine Dendrimers
    Kaminskas, Lisa M.
    Kelly, Brian D.
    McLeod, Victoria M.
    Sberna, Gian
    Boyd, Ben J.
    Owen, David J.
    Porter, Christopher J. H.
    [J]. MOLECULAR PHARMACEUTICS, 2011, 8 (02) : 338 - 349